Research advances in the therapeutic effect of mesenchymal stem cell exosomes on pulmonary hypertension

Abstract:

Pulmonary hypertension（PH） is a disease characterized by progressive pulmonary vasoconstriction， pulmonary vascular remodeling，and right ventricular hypertrophy，finally leading to right heart failure. At present，there are still insufficiencies in the treatment methods for PH， and it is needed to develop new treatment strategies. In recent years，studies have been conducted on the therapeutic effect of mesenchymal stem cells（MSC） on PH and related mechanisms by scholars in China and globally，which has become one of the research hotspots of cell therapy for PH，and among them，the paracrine mechanism of MSC is considered to have an important therapeutic effect. Exosomes（EXO） isolated from MSC have the potential to inhibit pulmonary vascular remodeling and are considered as a new potential treatment method for PH. This article reviews the role and possible mechanism of MSC EXO in the treatment of PH，so as to provide a theoretical basis for the treatment of PH by MSC EXO in the future.