Correlation between serum KLF5 content and positive lymph node ratio and its predictive value for prognosis of patients with bladder cancer after radical operation

Abstract:

Objective To explore the correlation between serum recombinant Kruppel factor 5（KLF5） content and positive lymph node ratio and its predictive value for the prognosis of patients with bladder cancer after radical operation.Methods Ninety-two patients in Department of Urinary Surgery，Xinxiang Central Hospital and The First Affiliated Hospital of Zhengzhou University with bladder cancer treated by radical cystectomy from June 2019 to September 2022 were selected for the study，and they were divided into effective and ineffective groups according to their efficacy. The expression level of serum KLF5 was obtained by enzyme-linked immunosorbent assay. The correlation between serum KLF5 content and positive lymph node ratio and its predictive value for prognosis were analyzed.Results The expression level of serum KLF5 in patients in the effective group was significantly lower than that in the ineffective group（P<0.05）； the positive lymph node ratio in patients in the effective group was significantly different compared with that in the ineffective group（P<0.05）. Pearson analysis showed that a positive correlation was found between serum KLF5 and positive lymph node ratio（odds ratio=0.607；P=0.000）. Multivariate logistic regression analysis showed that serum KLF5（OR=2.751，95%CI=1.777-4.260，P=0.000） and positive lymph node ratio（OR=2.751，95%CI=1.389-7.342，P=0.006） were independent risk factors affecting the prognosis of patients undergoing radical cystectomy（P<0.05）. The receiver operating characteristic curve results showed that the areas under the curve（AUCs） of serum KLF5 and positive lymph node ratio were 0.909 and 0.748，respectively，for predicting the prognosis of patients undergoing radical cystectomy. The corresponding sensitivity was 80.71% and 93.26%，and the specificity was 91.24% and 92.50%，respectively. The AUC for the combined diagnosis of the two indicators was 0.929，with a sensitivity and specificity of 92.30% and 92.50%，respectively.Conclusion Serum KLF5 and positive lymph node ratio are independent risk factors for the prognosis of patients undergoing radical cystectomy，and KLF5 is positively correlated with positive lymph node ratio in patients undergoing radical cystectomy. Therefore，in the process of predicting the prognosis of patients undergoing radical cystectomy，dynamic detection of changes in related influencing factors can provide a basis for clinicians to diagnose the disease.