Correlations of serum transforming growth factor，alkaline phosphatase，and prostate-specific antigen with metastatic castration-resistant prostate cancer

Abstract:

Objective To investigate the correlations of serum transforming growth factor（TGF）-β1，prostate-specific antigen（PSA），and alkaline phosphatase（ALP） with the occurrence of metastatic castration-resistant prostate cancer（mCRPC） in patients with prostate cancer bone metastases.Methods Using the method of retrospective study，patients diagnosed with bone metastasis of prostate cancer in Guangdong Provincial Hospital of Chinese Medicine from January 2022 to February 2023 were selected and divided into CRPC group（26 cases） and non-CRPC group（29 cases）. The general information of patients was collected，and the levels of serum TGF-β1，ALP，and PSA were measured using enzyme-linked immunosorbent assay.Results Univariate analysis was performed between the two groups. The difference in serum PSA was not significant（P>0.05），while the differences in serum TGF-β1 and ALP were statistically significant（P<0.05）. Binary logistic regression analysis showed that TGF-β1 was an independent risk factor for the occurrence of mCRPC. Spearman correlation analysis showed a positive correlation between serum TGF-β1 and ALP in patients with mCRPC.Conclusion TGF-β1 and ALP levels are closely related to the invasion and progression of prostate cancer bone metastases. Our results may provide a basis for evaluating the treatment and prognosis of patients with prostate cancer bone metastases.