Clinicopathological and perioperative clinical characteristics of patients with pheochromocytoma of different ages

Abstract:

Objective To explore the clinicopathological characteristics and perioperative clinical characteristics of patients with pheochromocytoma of different ages，and to provide more theoretical bases for individualized treatment of patients with pheochromocytoma in clinical practice.Methods The clinicopathological and perioperative data of 213 patients with pheochromocytoma who were pathologically confirmed and surgically treated in our hospital from 2012 to 2022 were retrospectively analyzed，and the patients were divided into three groups according to age： youth，middle-aged，and elderly groups. The clinicopathological indices and perioperative characteristics of patients with pheochromocytoma in the three groups were compared and analyzed.Results There were significant differences in lesion size，intraoperative blood loss，body mass index，preoperative complications，admission symptoms，intraoperative blood pressure fluctuation，and pathological characteristics among the three groups（P<0.05）. The elderly group had the largest lesion diameter，the highest proportion of positive NSE in postoperative biopsy pathology，and the highest incidence of postoperative nutrition-related complications. The youth group had the highest positive rate of Ki-67，the highest proportion of pheochromocytoma-related symptoms on admission，and the highest incidence of hypertension crisis and intraoperative bleeding. The middle-aged group had the highest incidence of intraoperative blood pressure fluctuation，but shorter total length of hospital stay.Conclusion Pheochromocytoma patients of different age groups have variability in postoperative complications，admission symptoms，and intraoperative blood pressure fluctuations，so treatment should be individualized for patients of different ages.