Factors affecting the outcome of partial nephrectomy in patients with stage T1 renal cancer

Abstract:

Objective To analyze the factors affecting the outcome of partial nephrectomy（PN） in patients with stage T₁ renal cancer.Methods A retrospective analysis was conducted on the data of 219 patients with stage T₁ renal cancer who underwent PN in the First Affiliated Hospital of Chongqing Medical University from September 2020 to May 2022. Patients were divided into two groups according to tumor stage：T_1a group and T_1b group. Patients’ general data，tumor characteristics，intraoperative and postoperative data were analyzed. PN that simultaneously met four elements of negative surgical margins，renal warm ischemia time <30 min，no grade 3 or higher postoperative complications，and no intermediate conversion to radical nephrectomy was considered as a PN with good outcome，and with this as the observation endpoint，a logistic regression analysis was performed to analyze the factors affecting surgical outcome.Results Significant differences existed between the two groups in terms of maximum tumor diameter，RENAL score，operative time，estimated bleeding，renal warm ischemia time，number of cases with intermediate conversion to radical nephrectomy，creatinine uptake value，and number of cases meeting the four elements. The logistic regression analysis showed that RENAL score was the main factor affecting surgical outcome.Conclusion RENAL score is a key influencing factor for the outcome of PN in patients with stage T₁ renal cancer.