Impact of laparoscopic nephron-sparing nephrectomy on renal function and prognosis in patients with renal cell carcinoma

Abstract:

Objective To analyze the impact of laparoscopic nephron-sparing nephrectomy on renal function and prognosis in patients with renal cell carcinoma.Methods A total of 182 patients with renal cell carcinoma in Department of Urology，The First Affiliated Hospital of Chongqing Medical University were enrolled from January 2017 to March 2022. The patients were randomly assigned to undergo laparoscopic radical nephrectomy（control group，91 patients） or laparoscopic nephron-sparing nephrectomy（study group，91 patients）. Postoperative renal function and prognosis of the two groups were compared.Results The study group was significantly better than the control group in the length of hospital stay（P=0.011），and the control group was significantly better than the study group in intraoperative bleeding volume（P<0.001） and operation time（P=0.019）. Compared with the control group，the study group showed a significantly lower serum creatinine level 24 hours after surgery（P=0.013） and significantly higher scores of cognitive function（P=0.018），physical function（P=0.021），social function（P=0.025），emotional function（P=0.032），and overall quality of life（P=0.033） after surgery.Conclusion Laparoscopic nephron-sparing nephrectomy can lessen the impact on renal function and improve postoperative quality of life for patients with renal cell carcinoma.