Sellar space-occupying diseases and sex hormone replacement therapy

Abstract:

There are many causes of acquired central hypogonadism，among which sellar space-occupying diseases are important factors. Gonadal hormone replacement therapy can restore sexual function，improve metabolism and quality of life，and enhance self-confidence. In this study，sellar space-occupying diseases are classified into three categories；estrogen receptor-positive or estrogen-related tumors，estrogen receptor-negative or ambiguous tumors，and non-tumoral sellar space-occupying diseases. This article reviews each type of sellar space-occupying diseases，the influence of treatment interventions on gonadal function，and the precautions for sex hormone replacement therapy under different circumstances，in order to provide advice and help for the treatment of patients with such diseases. Meanwhile，this article also puts forward thoughts on several issues at present and calls for more clinical observation studies and basic researches to further improve sex hormone replacement therapy for patients with sellar space-occupying diseases.