Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease

Abstract:

Objective To evaluate the relationship between the monocyte-to-lymphocyte ratio（MLR） and lower extremity arterial disease（LEAD） in patients with diabetic foot disease.Methods We included a total of 243 patients with type 2 diabetic foot problems hospitalized in The First Affiliated Hospital of Army Medical University from April 2020 to April 2023. They were divided into LEAD group（n=103） and non-LEAD group（n=140） to analyze the relationship between MLR and LEAD.Results The MLR in the LEAD group was significantly higher than that in the non-LEAD group（0.46［0.29，0.63］ vs. 0.38［0.26，0.58］，P<0.05）. The logistic regression analysis showed that MLR，age，serum cholesterol，and serum creatinine were risk factors for LEAD in patients with diabetic foot disease（P<0.05）. The receiver operating characteristic curve analysis showed that the optimal cut-off point for MLR predicting lower extremity arterial disease in patients with diabetic foot problems was 0.34，with sensitivity and specificity being 69.9% and 46.4%，respectively.Conclusion MLR is associated with the development of LEAD in patients with type 2 diabetic foot disease.