Clinical efficacy of Liraglutide combined with metformin in overweight or obese patients with PCOS

Abstract:

Objective To review the clinical efficacy of liraglutide combined with metformin in the treatment of overweight or obese patients with polycystic ovarian syndrome（PCOS）.Methods 125 patients with PCOS from The First Affiliated Hospital of Army Medical University who met the inclusion criteria from June 2018 to April 2023 were selected as study subjects and divided into hyperrecombination（n=56） and obesity group（n=69） according to body mass index（BMI）≥24 kg/m². Both groups were treated with Liraglutide combined with metformin for 12 weeks to evaluate the clinical efficacy after treatment.Results ①After treatment，the body weight，BMI，waist circumference，hip circumference and alanine aminotransferase in two groups were decreased（P<0.05）. The decrease of body weight and BMI in obese group was more significant（P<0.05）. After treatment，the indexes of glucose and lipid metabolism were decreased in both groups（P<0.05），but there was no significant difference in absolute value between the two groups（P>0.05）. After treatment，sex hormone globulin increased，while total testosterone，free androgen index，luteinizing hormone，luteinizing hormone/follicle-stimulating hormone decreased（P<0.05），and superrecombinant decreased more significantly（P<0.05）. After treatment，the recovery rate of menstruation and dominant follicle formation rate were improved，and the polycystic changes of ovary were decreased（P<0.05）.②The most common adverse reactions in the two groups were nausea，diarrhea and dyspepsia. All of the adverse reactions were gradually reduced within 4 weeks of administration.Conclusion Liraglutide combined with metformin has good efficacy in reducing body weight and body mass index in overweight or obese PCOS patients，improving glycemic and lipid metabolism disorders and ovarian function，especially in obese PCOS patients with more benefits in reducing body weight，and patients with super severe PCOS have more advantages in improving sex hormone levels.