Clinical observation on 14 cases of inflammatory bowel disease treated by fecal microbiota transplantation

Abstract:

Objective To observe the safety and efficacy of fecal microbiota transplantation in the treatment of inflammatory bowel disease，and to evaluate the effect on inflammatory indexes，disease scores，and composition of gut microbiota after treatment.Methods A total of 14 patients with inflammatory bowel disease who underwent fecal microbiota transplantation in the Anorectal Department of our hospital from December 2018 to December 2021 were selected to compare the clinical efficacy，inflammatory indexes，Mayo and CDAI disease scores，and to compare the composition of gut microbiota by 16s rDNA detection before and after treatment.Results After fecal microbiota transplantation，the clinical remission rate was 85.71%（13/15） in the 15th week；the inflammatory indexes，Mayo and CDAI disease scores，diversity and relative abundance of gut microbiota were improved，and the differences were statistically significant（P<0.05）.Conclusion Fecal microbiota transplantation in the treatment of inflammatory bowel disease has a significant curative effect，few adverse reactions，and high safety，which is worthy of clinical application.