Risk factors for cognitive dysfunction in patients with brain infarction and type 2 diabetes

Abstract:

Objective To identify the risk factors for cognitive dysfunction in patients with brain infarction and type 2 diabetes（T2D），and to offer insights for the diagnosis and treatment of cognitive dysfunction.Methods In this retrospective study，data were collected from patients with brain infarction complicated with T2D，who were admitted to Xijing Hospital，Air Force Medical University from January 2010 to December 2021. A total of 191 eligible patients were divided into cognitive dysfunction group（CD group） and non-cognitive dysfunction group（Non-CD group） according to mini-mental state examination. Data were collected on demographic characteristics，clinical features，and biochemical markers.Results The univariate analysis showed significant correlations of cognitive dysfunction with age，education level，degree of dependence，duration of T2D，D-dimer，and fibrinogen degradation products（P<0.05）. The multivariate logistic regression and receiver operating characteristic curve showed that age（OR=2.249，95%CI=1.172-4.319，P=0.015） and education level（OR=0.587，95%CI=0.352-0.978，P=0.041） were significant risk factors for cognitive dysfunction in patients with brain infarction and T2D.Conclusion Age and education level are tightly related to brain infarction and T2D，and are risk factors for cognitive dysfunction.