Exploring the clinical prognostic factors in endometrial stromal sarcoma

Abstract:

Objective To perform a retrospective analysis of the clinical outcome of patients with endometrial stromal sarcoma（ESS） and to identify prognostic factors.Methods A total of 82 ESS patients were recruited from June 2009 to March 2020 in The First Affiliated Hospital of Chongqing Medical University. Their clinical data were collected and analyzed，including age，body mass index，menopausal status，tumor size，lymph node resection，ovarian preservation，histological type，stage，adjuvant therapy，and CD10. All patients were followed up. Statistical analysis was performed using SPSS 25.0，the Kaplan-Meier method and log-rank test were used for survival analysis，and Cox regression was used to analyze the prognostic factors.Results A total of 82 patients with ESS were enrolled in this study. The follow-up time was 2-132 months，and the 5-year cumulative overall survival rate was 71.8%. Univariate analysis showed that menopausal status，ovarian preservation，histological type，stage，and indices（ER，PR，and Ki-67） were significantly correlated with progression-free survival. While menopause status，tumor size，histological type，stage，and indices（ER，PR，and Ki-67） were significantly correlated with overall survival. Histological type and ovarian preservation were independent prognostic factors for progression-free survival（P=0.010，0.013），while histological type was an independent prognostic factor for overall survival（P=0.033）.Conclusion There are many factors that affect the prognosis of ESS，and histological type and ovarian preservation are independent prognostic factors for ESS.