Research progress of DYRK2 in tumor occurrence，development， and prognosis

Abstract:

Dual-specificity tyrosine-phosphorylation-regulated kinase 2（DYRK2） belongs to the DYRK family and is an evolutionarily conserved enzyme in eukaryotes. The expression of DYRK2 varies greatly in different tissues and tumors. Previous reports on the role of DYRK2 in tumors have shown that it can delay tumor growth by prolonging G₁ phase，promoting apoptosis，and inhibiting epithelial-mesenchymal transition. Recent studies have found that DYRK2 can also play a cancer-promoting role by enhancing cell mitosis，tumor apoptosis resistance，cell invasion and migration，and drug resistance. Here we present a review of the structure and function of DYRK2 as well as its roles in tumor occurrence，development，and prognosis.