Research advances in the role of vitamin D in female fertility and reproductive system diseases

Abstract:

Vitamin D receptor（VDR） is widely expressed in female reproductive organs，and vitamin D binds with VDR to regulate bone and calcium homeostasis and participate in various signaling pathways such as inflammation，cell-mediated immunity，cell cycle，and apoptosis inside the body. Vitamin D regulates follicular development，ovarian reserve，and endometrial receptivity，and vitamin D deficiency is associated with the pathological process of polycystic ovary syndrome. Vitamin D supplementation is of great significance in preventing premature ovarian failure，uterine myoma，endometriosis，and ovarian cancer. The level of vitamin D inside the body is also associated with the outcome of in vitro fertilization. Vitamin D deficiency is a major public health problem，and reasonable supplementation of vitamin D may help to maintain female reproductive health.