Interaction between lifestyle and family history on cardiometabolic diseases

Abstract:

Objective To investigate the influence of lifestyle and family history of cardiometabolic diseases on the risk of cardiometabolic diseases and the interaction between lifestyle and family history，and to guide disease prevention and control.Methods A total of 3009 permanent residents，aged 30-79 years，in Hechuan District were selected as subjects according to the inclusion and exclusion criteria，and a questionnaire survey，physical examination，and laboratory tests were performed. SPSS 26.0 was used to perform the chi-square test and the multivariate logistic regression analysis，and the multiplicative model and the additive model were used to investigate the interaction between lifestyle and family history on the onset of cardiometabolic diseases.Results There was neither multiplicative interaction（OR_int=1.22，95%CI=0.86-1.73） nor additive interaction between lifestyle and family history on cardiometabolic diseases，with a relative excess risk due to interaction of 0.69（95%CI=-3.98 to 5.36），an attributable proportion of 0.21（95%CI=-0.95 to 1.37），and a synergy index of 1.44（95%CI=0.16-13.03）. The individuals with an unhealthy lifestyle and a family history of cardiometabolic diseases had a higher risk of cardiometabolic diseases than those with a healthy lifestyle and no family history（odds ratio[OR]=3.26，95%CI=2.52-4.23），and male individuals（OR=5.16，95%CI=3.12-8.52） had a higher risk than female individuals（OR=2.72，95%CI=1.96-3.77）.Conclusion There is no interaction between lifestyle and family history on the risk of cardiometabolic diseases，but there is a combined effect. For individuals with such family history，maintaining a healthy lifestyle may help to control cardiometabolic diseases.