Research progress on the mechanisms of mechanical stress affecting cell pyroptosis

Abstract:

Pyroptosis is a type of cell death that culminates in the loss of membrane integrity as a result of the activation of inflammasome sensors. Pyroptosis plays an important role in the development and progression of inflammation and diseases because of a leakage of the cellular contents into the extracellular space. Cells live in a complex mechanical environment and are subject to various mechanical stimuli originating from the microenvironment and external forces. Appropriate mechanical stress contributes to the normal physiological process of cells，but excessive mechanical stress can activate stress signaling pathways，such as death pathways，resulting in cell tissue damage and inflammation. In this paper，we review the literature on the molecular mechanisms of cell pyroptosis and how mechanical stress affects cell pyroptosis，aiming to provide a basis for future research on pyroptosis-related diseases.