Correlation between liver/spleen stiffness and hepatic venous pressure gradient in patients with viral liver cirrhosis

Abstract:

Objective To investigate the change in liver/spleen stiffness and the correlation with hepatic venous pressure gradient （HVPG） in patients with viral liver cirrhosis.Methods We included 82 patients with viral liver cirrhosis treated in The Second People's Hospital of Lanzhou from September 2020 to December 2021. HVPG and liver and spleen stiffness were measured. Pearson correlation analysis was used to evaluate the correlation between changes in liver and spleen stiffness and HVPG in these patients. A receiver operating characteristic（ROC） curve was used to evaluate the predictive value of liver and spleen stiffness for HVPG ≥12 mmHg in patients with viral liver cirrhosis.Results HVPG，liver stiffness，and spleen stiffness were significantly higher in the Child-Pugh class B patients and the Child-Pugh class C patients than in the Child-Pugh class A patients（P<0.05）. HVPG was significantly positively correlated with liver stiffness and spleen stiffness（r=0.591，0.502，P<0.001）. The areas under the ROC curves for predicting HVPG ≥12 mmHg using liver stiffness，spleen stiffness，and their combination in patients with liver cirrhosis were 0.866，0.821，and 0.914，respectively.Conclusion Liver and spleen stiffness are significantly positively correlated with HVPG in patients with viral liver cirrhosis， which have certain predictive value for portal hypertension in a noninvasive way.