Advances in pharmacotherapy for the acute stage of acute ischemic stroke

Abstract:

Stroke ranks first among the causes of death and disability in Chinese adults. Acute ischemic stroke（AIS） is the most common type of stroke that seriously affects the quality of life of patients and imposes a heavy disease burden，and therefore，the prevention and treatment of AIS is a major problem that needs to be addressed urgently. AIS has a complex pathogenesis，and overall assessment of patients should be performed to make a comprehensive decision，while following the standardized diagnosis and treatment process. There are currently two main therapeutic strategies for the acute stage of AIS，i.e.，timely recanalization of the obstructed vessels to restore the perfusion of brain tissue and rescue the ischemic penumbra and inhibition of the ischemic cascades through multiple targets to protect brain cells. In recent years，rapid progress has been made in pharmacotherapy for AIS in the fields of thrombolysis，antiplatelet therapy，and cytoprotection. With reference to related research findings in China and globally，this article reviews the advances in pharmacotherapy for the acute stage of AIS，in order to provide a scientific basis and ideas for the research and development of other effective therapeutic drugs.