Advances in the treatment of frontotemporal dementia

Abstract:

Frontotemporal dementia（FTD） is a group of neurodegenerative diseases with diverse clinical phenotypes，complex genetic factors，and highly heterogeneous neuropathology，and it is characterized by progressive changes in personality and behavior，executive dysfunction，and speech and language impairment. Currently，there are no effective treatment methods that can cure FTD or reverse its progression，and in clinical practice，symptomatic treatment strategies are often used to improve the neuropsychiatric，motor，and cognitive symptoms of patients with FTD. With in-depth studies on the pathogenesis of FTD，clinical trials are being conducted for an increasing number of drugs that target the mutant genes and neuropathology of FTD，in order to achieve early management and precise treatment. This article reviews the advances in the treatment of FTD，so as to help clinicians understand the latest information for the treatment of FTD and improve disease management.