Advances in invasive neuromodulation therapy for gait disturbance in Parkinson's disease

Abstract:

Gait disturbance is one of the most common axial symptoms in Parkinson's disease（PD），and it severely impairs the mobility and quality of life of patients. Neuromodulation is an important therapy in addition to pharmacotherapy，exercise，and rehabilitation，among which invasive surgery is a commonly used modulation method. Due to the high prevalence rate of gait disturbance in PD and the limitations of existing therapies，studies for new targets and techniques have been conducted for invasive neuromodulation in recent years. This article reviews the advances and prospects of invasive neuromodulation in the treatment of gait disturbance in PD.