Treatment for preventing the recurrence of neuromyelitis optica spectrum disorders with positive aquaporin-4 immunoglobulin G antibody

Abstract:

Neuromyelitis optica spectrum disorders（NMOSD） is an autoimmune-mediated central nervous system disorder characterized by optic neuritis and transverse myelitis. NMOSD is mainly caused by aquaporin-4（AQP4） immunoglobulin G（IgG） antibody and has the characteristics of high recurrence and disability rates. Each time of recurrence may lead to gradual accumulation of nerve damage and disability，and therefore，drugs for effective prevention of recurrence should be used as early as possible to reduce recurrence rate and improve the long-term prognosis of patients. At present，with the in-depth studies on the pathogenesis of NMOSD， new monoclonal antibody drugs for corresponding targets continue to emerge. This article reviews the treatment methods for preventing the recurrence of NMOSD with positive AQP4-IgG antibody in the chronic stage.