Advances in the treatment of radiation-induced brain injury

Abstract:

Although radiotherapy can significantly increase the survival rate of patients with head and neck tumors， it also causes damage to the surrounding normal brain tissue， resulting in radiation-induced brain necrosis and cognitive decline， which shows an incidence rate up to 90% and seriously affects the quality of life of patients. In recent years， researchers have explored the potential etiologies of radiation-induced brain injury（RIBI） at various levels and have identified different types of targets for intervention， providing new strategies for the prevention and treatment of radiation-induced damage. This article reviews the mechanisms of the development and progression of RIBI and related pharmaceutical and non-pharmaceutical interventions and proposes the current challenges and future research directions of this field.