Advances in pharmacological treatment of schizophrenia

Abstract:

Schizophrenia is one of major mental disorders leading to severe mental disabilities，imposing a substantial burden on the society and patients and their families. Advances in science and technology have not only promoted the re-development of traditional medications，but also fostered the emergence of novel drugs like xanomeline-trospium，emraclidine，and trace amine-associated receptor 1，which offer more personalized and effective treatment options. This article delves into the clinical effectiveness and mechanisms of action of these drugs as well as the challenges from the introduction of new medications，such as drug discontinuation，side effects，and the establishment of animal models for drug prediction. Insights into future research directions are provided. We aim to explore the latest progress in schizophrenia medications，offering up-to-date references for researchers and clinicians.