Meta analysis on the relationship between gene CACNA1C polymorphism and schizophrenia

Abstract:

Objective：To assess the associations of Calcium channel，voltage-dependent，L type，alpha1C subunit gene（CACNAIC）gene polymorphism with schizophrenia by Meta analysis and to provide evidence-based medicine references for the genetic back－ground of schizophrenia. Methods：Literatures on the relationship between gene CACNA1C polymorphism rs1006737 and schizophre－nia both in PubMed and China Biology Medicine Databases were taken as research objects from January 2000 to November 2013. Statistical analysis was performed with RevMan 5.1 including the heterogeneity，odd ratio and evaluation on publication bias. Results：Five literatures meeting the criteria were included including 3 555 cases of schizophrenia and 19 566 cases of healthy controls. There was significant association between CACNA1C polymorphism rs1006737 and schizophrenia. The subgroups were Caucasian and Asian and there was no significant heterogeneity between subgroups. The summary OR for studies in Caucasian and Asian with the frequency of（G/A+A/A vs. G/G） genotype was 1.16（95%CI=1.03 to 1.31，Z=2.39） and 1.29（95%CI=1.10 to 1.52，Z=3.09），with significant differences（both P<0.05）. Conclusion：There is significant association between CACNA1C polymorphism rs1006737 A gene and schizophrenia. rs1006737 polymorphism may contribute to susceptibility of schizophrenia in Caucasian and Asian. CACNA1C polymorphism rs1006737 A gene may confer the risk of schizophrenia as an independent risk factor.