TNF-α-308 G/A gene polymorphism and risk of chronic periodontitis：a Meta analysis

Abstract:

Objective：To evaluate the association between TNF-α-308 G/A gene polymorphism and the risk of chronic periodontitis（CP）. Methods：A Meta analysis was performed to analyze the association between TNF-α-308 gene polymorphism and the risk of CP. Studies on correlation between TNF-α-308 G/A gene polymorphism and susceptibility to CP were systematically retrieved from PubMed，Embase，CNKI，CBM，VIP and WanFang Data. Academic level of studies included in this article was assessed according to the Newcastle-Ottawa Scale（NOS）. Meta analysis was carried out using the Review Manager（version 5.2.0） and Stata（version 12.0）. Results：A total of 18 case-control studies（1 420 cases，1 538 controls） were included in this Meta analysis. The results showed no statistically significant difference in all genotype models between CP cases and controls：allele genetic model A vs. G（OR=1.05，95%CI=0.83 to 1.34，P=0.68），additive genetic model AA vs. GG（OR=1.35，95%CI=0.78 to 2.34，P=0.28），dominant model AA+AG vs. GG （OR=1.02，95%CI=0.79 to 1.33，P=0.88），recessive model AA vs. AG+GG（OR=1.42，95%CI=0.82 to 2.45，P=0.21）. In the subgroup analysis by ethnicity，severity and smoking status，no statistically differences was found between CP cases and controls（P >0.05）. Conclusion：TNF-α-308G/A gene polymorphism may not be a risk factor of CP. Due to the limited quantity of the included studies；further studies are needed to validate the above conclusion.