Abstract:Imbalance of vascular homeostasis and vascular remodeling play a key role in tumor-line specific vascular abnormalities. Tumor vasculature normalization develops new anti-vascular therapies in conventional tumor therapy，and it can effectively improve chemotherapy resistance due to vascular abnormality and radiotherapy tolerance caused by local hypoxia and thus increases the effec－tiveness of multimodality therapy. Recent studies have shown that vascular leakage allows tumor cells to escape antitumor immunolog－ical surveillance. Moreover，hypoxic tumor microenvironment caused by low oxygen partial pressure can further improve immune toler－ance and eliminate tumor immunity，suggesting that recovery of oxygen content in tumor and repair of abnormal vessels，combined with chemotherapy，may bring new hope to antitumor therapies in future. Recent studies have found that some vascular microRNAs are involved in the regulation of tumor immunity and metastasis. This article reviews the recent advances in microRNAs in regulating abnormal angiogenesis and tumor immune response，as well as the role of key mocroRNA targets involved in tumor vasculature nor－malization in antitumor immune response.

Abstract:There is an interaction between the interleukin-6（IL-6） and estrogen signaling pathways，and more importantly，the inter－action between these two signaling pathways plays an important in the development and progression of related diseases. Studies have shown that estrogen receptor can affect the development and severity of many diseases including breast cancer by regulating the ex－pression of the IL-6/STAT3 pathway；on the other hand，mutations of the estrogen and IL-6 genes are closely associated with various diseases. The interaction between the IL-6 and estrogen signaling pathways is of great significance in disease treatment，and treatment regimens based on these two signaling pathways bring hope to patients who have resistance to single-signal pathway therapy and hormone-related side effects and has a significant clinical value. This article reviews the influence of the interaction between the IL-6 and estrogen pathways on a variety of diseases，in order to provide new ideas for the treatment of diseases.

Abstract:Leptomeningeal metastasis（LM） is a common complication of advanced non-small cell lung cancer（NSCLC）. About 5%-10% of patients with advanced NSCLC may experience LM，and a lack of effective treatment leads to an extremely short survival time of these patients. Although there are various treatment methods for NSCLC patients such as platinum-based dual-drug chemotherapy，whole-brain radiotherapy，and intrathecal injection，they often have limited effects in improving patients’ survival time. In recent years，biologically targeted therapy has become one of the hot research fields. Epidermal growth factor receptor-tyrosine kinase in－hibitors，anaplastic lymphoma receptor tyrosine kinase inhibitor，and anti-angiogenic drugs have been used in the treatment of NSCLC patients with central nervous system metastasis. Previous studies have demonstrated that these biologically targeted drugs can effec－tively prolong the survival time of NSCLC patients. This article reviews the research advances in biologically targeted therapy for NSCLC patients with LM.

Abstract:Medulloblastoma（MB） is a common tumor in the central nervous system of children. It has a poor prognosis after surgery alone and severe side effects with adjuvant radiotherapy. Chemotherapy is an important adjuvant treatment for children with MB，but there is no standard chemotherapy. Studies have shown that the standard-risk group can improve survival rate and reduce side effects through intensified chemotherapy and dose-reduced radiotherapy. In the high-risk group，children more than 3 years old can use radiotherapy and intensified chemotherapy combined with stem cell transplantation to improve survival rate. Radiotherapy should be avoided in children aged ≤3 years with MB，and prognosis can be improved by intraventricular application of methotrexate and intensified chemotherapy combined with autologous stem cell transplantation. The duration of chemotherapy is still uncertain. In this article，the application of MB chemotherapy，the timing of chemotherapy，and the sequence of radiotherapy and chemotherapy in MB groups with different levels of risk are reviewed.

Abstract:Objective：To study the effect of S-adenosylmethionine（SAM） on the proliferation and migration of bladder cancer（BCa） cells via hepatocyte cell adhesion molecule（hepaCAM） and its potential molecular mechanism. Methods：T24 and BIU cells cultured in vitro were treated with different concentrations of SAM，and the effect of SAM on cell proliferation was evaluated by MTT assay. After treatment of T24 and BIU cells with different concentrations（0，0.8，1.6 mmol/L） of SAM for 72 h，real-time PCR and Western blot were used to measure the expression of methyl-CpG-binding domain protein 2（MBD2），histone deacetylase 1（HDAC1），and hepaCAM；wound healing assay and Transwell assay were used to measure the migration of cells in each group；colony formation assay was used to measure the colony formation ability of cells in each group. Results：SAM showed an inhibitory effect on the growth of T24 and BIU cells in a manner positively correlated with the con－centration and duration of treatment. After treatment of T24 and BIU cells with 0.8 mmol/L SAM for 72 h，the mRNA and pro－tein expression levels of MBD2 decreased significantly com－pared with those in the 0 mmol/L group（mRNA：P=0.048 and 0.038，respectively；protein：P=0.001 and 0.000，respectively）；the mRNA expression level of HepaCAM increased significantly（P=0.003 and 0.008，respectively），but there were no significant differences in the protein expression level of HepaCAM（P=0.770 and 0.381，respectively）. After treatment of T24 cells with 0.8 mmol/L SAM for 72 h，the mRNA and protein expression levels of HDAC1 decreased significantly（P=0.000 and 0.001，respectively）；after treatment of BIU cells with 0.8 mmol/L SAM for 72 h，the protein expression level of HDAC1 decreased significantly（P=0.004），but there was no sig－nificant difference in the mRNA expression level of HDAC1（P=0.14）. After the treatment of T24 and BIU cells with 1.6 mmol/L SAM for 72 h，there were significant decreases in the mRNA and protein expression levels of MBD2（mRNA：P=0.003 and 0.000，re－spectively；protein：P=0.001 and 0.000，respectively） and HDAC1（mRNA：P=0.000 and 0.000，respectively；protein：P=0.001 and 0.000，respectively），but there were significant increases in the mRNA and protein expression levels of hepaCAM（all P=0.000）. After treat－ment of T24 and BIU cells with SAM for 72 h，cell migration was significantly inhibited as demonstrated by the wound healing assay and Transwell assay（P<0.05），and cell colony formation ability was significantly reduced as demonstrated by the colony formation assay（P<0.05）. Conclusion：SAM can inhibit the proliferation and migration of BCa cells by reversing the expression of hepaCAM via MBD2/HDAC1.

Abstract:Objective：To screen out the active components in Radix Hedysari that maintain the biological stability of bone marrow stromal cells（BMSCs） induced by interleukin-6（IL-6） using molecular docking. Methods：The glide module of Schroding2015 soft－ware was used for molecular docking with 43 small-molecule compounds of Radix Hedysari as ligands and interleukin-6 receptor （IL-6R） as a target protein；small-molecule compounds with relatively good docking scores and having drug-likeness were selected and tested for binding affinity for IL-6R by microscale thermophoresis（MST）；then the binding curves were fitted and the binding levels were calculated. Results：Small-molecule compounds with a relatively good geometrical match with IL-6R and having drug-likeness screened out by molecular docking were quercetin，vestitol，and 1，5，8-trihydroxy-3-methoxy-9H -xanthen-9-one，among which the former two showed relatively good binding affinity for IL6R in the MST assay. Conclusion：Quercetin and vestitol may be the active components in Radix Hedysari that maintain the biological stability of BMSCs induced by IL-6.

Abstract:Objective：To isolate and identify cancer-associated fibroblasts（CAFs） from human lung adenocarcinoma tissue，to investi－gate the effect of CAFs on the proliferation and migration of lung cancer cells，and to lay a foundation for further research on the role and mechanism of CAFs in the development and progression of lung cancer. Methods：Surgical specimens were obtained from patients with lung adenocarcinoma，and fibroblasts were isolated and cultured. A phase-contrast optical microscope was used to observe cell morphology，and indirect immunofluorescence assay was used to measure the expression of key molecular markers. CCK-8 assay was used to evaluate cell proliferation，flow cytometry was used to analyze cell cycle，and Transwell assay was used to assess cell migration ability. The co-culture method and a conditioned medium were used to analyze the effect of CAFs on the proliferation and migration of lung adenocarcinoma A549 cells，and qRT-PCR was used to measure the change in the expression of key genes. Results：CAFs were isolated from fresh human lung adenocarcinoma tissue，with a spindle-like shape. Immunofluorescence assay showed the expression of the fibroblast markers fibronectin and Vimintin in CAFs，while epithelial keratin 8/18 was not found in CAFs. The CAFs isolated from lung adenocarcinoma tissue showed active proliferation and significantly promoted the proliferation and migration of A549 cells and remarkably upregulated the mRNA expression of c-Myc，PIM1，SOCS3，and CCND1 in A549 cells. Conclusion：CAFs are successfully isolated from human lung adenocarcinoma tissue and such CAFs can significantly promote the proliferation and migration of lung cancer cells.

Abstract:Objective：Prostate cancer is the most common tumor in the urinary system. Tomato and other foods containing lycopene are effective in preventing prostate cancer and slowing down its development，but the mechanism of action of lycopene on prostate cancer is not clear. In this study，bioinformatics methods were used to explore the potential targets of lycopene acting on prostate cancer，which is helpful to further elucidate the molecular mechanism of action of lycopene in prostate protection and other potential applications. Methods：The microarray dataset of gene expression from prostate cancer tissues of patients supplemented with lycopene and placebo as control before and after treatment were searched for and downloaded from gene expression omnibus（GEO）. The gene co-expression module was constructed by weighted gene co-expression network analysis. GO and KEGG cluster analyses and hub gene screening were performed on modules highly associated with traits. Results：A total of 16 co-expression modules were constructed from 114 samples in the dataset GSE27140. Two of the co-expression modules were highly associated with traits，which involved in epithelial-mesenchymal cell transformation，sister chromatid separation，cell senescence and other signaling pathways. Two hub genes were identified through further analysis of module gene connectivity. Conclusion：This study has screened out the potential targets of lycopene in the treatment of prostate cancer，which provides a meaningful clue for elucidating the mechanism of action of lycopene.

Abstract:Objective：To investigate the expression profile of exosomal microRNAs（miRNAs） in ovarian endometriosis（OEM）. Methods：The microarray technique was used to analyze the exosomal miRNAs of eutopic endometrial stromal cells in three patients with OEM and 3 healthy controls，in order to screen out the differentially expressed miRNAs. Results：A total of 12 differentially expressed microRNAs were screened out；hsa-mir-6829-5p，hsa-mir-5188，hsa-mir-4430-hsa-mir-584-5p，hsa-mir-4485-5p，and hsa-mir-4257 were up-regulated in the case group，while hsa-mir-188-5p，hsa-mir-4741，hsa-mir-4516，hsa-mir-1229-5p，hsa-mir-7150，and hsa-mir-5787 were downregulated. Target gene prediction，gene ontology analysis，and pathway analysis were performed for exosomal miRNAs with significant differential expression，and the results showed that most of the biological functions of target gene aggregation were involved in the regulation of biological progression. Conclusion：There are differentially expressed exosomal miRNAs between OEM patients and healthy controls. The differentially expressed miRNAs have high specificity and can help to further clarify the pathogenesis of OEM and search for new diagnostic markers.

Abstract:Objective：To investigate differentially expressed microRNAs between different lung cell lines under hypoxic conditions，and to provide a reference for further research on the mechanism of action of microRNAs in lung cancer cells under hypoxia. Methods：A model of hypoxia was established. RNA was extracted from GLC-82 and A549 cells cultured under a hypoxic or normal oxygen concentration，and microarray assay and PCR were used to screen out differentially expressed microRNAs. TargetScanHuman 7.2 and cytoscape software were used to predict the targeted genes regulated by differentially expressed microRNAs and the signaling path－ways involving these target genes. Results：Under the hypoxic condition，3 microRNAs were upregulated and 30 were downregulated in A549 cells，while 2 microRNAs were upregulated and 31 were downregulated in GLC-82 cells. miR-192-5p showed an opposite change trend in these two cell lines，while the other microRNAs showed a similar change trend. Kyoto Encyclopedia of Genes and Genome and gene ontology analyses showed that the differ－entially expressed microRNAs were mainly involved in tumor-related signaling pathways，insulin signaling pathways，Ras sig－naling pathways，and oxygen metabolism. Conclusion：Differentially expressed microRNAs are found in lung cancer cell lines cultured under hypoxic or normal oxygen conditions，and there are also differentially expressed microRNAs between cells with different genetic backgrounds. The target genes of differentially expressed microRNAs are involved in a variety of cellular metabolic pathways and have the functions of oxygen metabolism and oxygen response.

Abstract:Objective：To explore the expression and function of long non-coding RNA（lncRNA） CASC9 in oral squamous cell carci－noma（OSCC），and to elucidate its potential mechanisms. Methods：The expression of CASC9 in OSCC tissues from 101 patients was determined by in situ hybridization assay，and the correlation between the expression of CASC9 and clinicopathological characteristics and survival were analyzed. CASC9 siRNA was transfected into the target OSCC cell line SCC15. The mRNA and protein expression levels of PI3K，AKT，and p-AKT in SCC15 cells were measured using qPCR and Western blot，and the proliferation，migration，and invasion of SCC15 cells were evaluated by CCK8 assay，flow cytometry，and Transwell assay，respectively. Results：The expression of CASC9 was significantly increased in OSCC tissues（P=0.000），and it was significantly positively correlated with tumor size，cervical lymph node metastasis，and clinical stage（P<0.05）. The overall survival was significantly shortened in OSCC patients with high expres－sion of CASC9（P=0.007）. CASC9 was an independent risk factor for OSCC（P<0.05）. After silencing of CASC9，the expression of PI3K and p-AKT was significantly reduced（P<0.05），and the proliferation，migration，and invasion of SCC15 cells were significantly attenuated（P<0.05）. Conclusion：CASC9 promotes OSCC progression by activating the PI3K/AKT pathway. CASC9 could potentially be a novel clinical prognostic marker and therapeutic target for OSCC.

Abstract:Objective：To investigate the expression of TNF-α-induced protein 2（TNFAIP2） in non-small cell lung cancer （NSCLC） and its effect on cell proliferation，apoptosis，migration，and invasion. Methods：RT-PCR was used to measure the mRNA expression of TNFAIP2 and immunohistochemistry was used to measure the protein expression of TNFAIP2 in NSCLC. The lentivirus-mediated short hairpin RNA of TNFAIP2（shRNA-TNFAIP2） and negative control lentivirus（shRNA-NC） were constructed and were used to infect H1299 cells，and then RT-PCR and Western blot were used to measure the efficiency of infection. Transwell assay was used to measure cell migration and invasion abilities，CCK-8 assay was used to measure proliferative capacity，flow cytometry was used to measure cell apoptosis，and Western blot was used to measure the changes in the protein expression of E-cadherin，N-cadherin，and vimentin. Results：The mRNA and protein expression of TNFAIP2 in NSCLC tissue was significantly higher that that in adjacent tissue. After TNFAIP2 was downregulated by lentivirus，compared with the shRNA-NC group，the shRNA-TNFAIP2 group had significant reductions in the number of migrated cells（170±11 vs. 329±31，P=0.001） and the number of invasive cells（75±10 vs. 135±8，P=0.001）. CCK-8 assay showed that the shRNA-TNFAIP2 group had a significantly lower absorbance value than the shRNA-NC group（P=0.000）；flow cytometry showed that the shRNA-TNFAIP2 group had a significantly higher apoptosis rate than the shRNA-NC group[（18.730±0.490）% vs. （6.570±0.870）%，P=0.000]；Western blot showed that compared with the shRNA-NC group，the shRNA-TNFAIP2 group had reductions in the protein expres－sion of N-cadherin and vimentin and an increase in the protein expression of E-cadherin. Conclusion：TNFAIP2 is highly ex－pressed in NSCLC. Downregulation of TNFAIP2 can inhibit cell proliferation，migration，and invasion，promote cell apoptosis，and re－verse epithelial-mesenchymal transition.

Abstract:Objective：To investigate the correlation of maximum standard uptake value（SUVmax），metabolic tumor volume（MTV），and total lesion glycolysis（TLG） on 18F-FDG PET/CT with patient age，Federation International of Gynecology and Obstetrics（FIGO） stage，pathological classification，carbohydrate antigen 125（CA125），human epididymis protein-4（HE4），proliferation antigen Ki-67，tumor suppressor gene protein p53，and Wilms tumor gene product WT1 in patients with ovarian cancer after surgery. Methods：A retrospectively analysis was performed for the clinical data of 80 patients with ovarian cancer who underwent 18F-FDG PET/CT，and the metabolic parameters including SUVmax，MTV，and TLG were calculated. A rank sum test was used to investigate the correlation of the metabolic parameters with age，FIGO stage，pathological classification，CA125，HE4，Ki-67，p53，and WT1. Results：The patients with stage Ⅲ/Ⅳ ovarian cancer had a significantly higher SUVmax than those with stage Ⅰ/Ⅱ ovarian cancer（Z=-1.985，P=0.047），and the patients with positive expression of WT1 had a significantly higher SUVmax than those with negative expression of WT1（Z=-2.101，P=0.036）. The patients with high expression of CA125 and HE4 had a significantly higher MTV than those with low expression（Z=-2.323 and -2.981，P=0.020 and 0.003）. The patients with high expression of Ki-67 had a significantly higher MTV than those with low expression（Z=-2.134，P=0.033），and the patients with positive expression of p53 and WT1 also had a significantly higher MTV than those with negative expression（Z=-1.970 and -2.290，P=0.049 and 0.021）. The patients with high expression of HE4 had a significantly higher TLG than those with low expres－sion（Z=-2.712，P=0.007）. The patients with high expression of Ki-67 had a significantly higher TLG than those with low expression（Z=-2.198，P=0.028），and the patients with positive expression of p53 and WT1 had a significantly higher TLG than those with negative expression（Z=-2.356 and -2.751，P=0.018 and 0.005）. Conclusion：There is a certain degree of correlation between 18F-FDG PET/CT metabolic parameters and clinical/pathological/biological factors in patients with ovarian cancer after surgery. SUVmax is correlated with FIGO stage and WT1，and CA125，HE4，Ki-67，p53，and WT1 are closely correlated with MTV and TLG representing the degree of tumor burden. To a certain degree，MTV and TLG can reflect some features of patients with recurrence and metastasis after surgery for ovarian cancer and help to determine the degree of tumor malignancy and predict patient prognosis.

Abstract:Objective：To explore the clinical significance of Ras and a-factor converting enzyme 1（Rce1） in the diagnosis of prostate cancer（PCa）. Methods：Blood samples from 96 patients with PCa and 133 patients with benign prostatic hyperplasia（BPH） as con－firmed by pathology from April 2017 to October 2018 were collected for Western blot and enzyme-linked immunosorbent assay （ELISA）. Meanwhile，another 30 patients with urinary calculi，cryptorchidism，and varicocele were treated as normal control group. Then levels of Rce1 in the blood specimens from these groups were analyzed to evaluate its performance in the diagnosis of PCa. Results：The PCa group had a significantly higher level of Rce1 compared with those of the BPH group and normal control group（93.25±15.14 pg/μL vs. 78.37±16.91 pg/μL and 77.73±12.04 pg/μL，P=0.000）. However，there was no significant difference between the BPH and normal control group regarding the level of Rce1（P=0.843）. Meanwhile，the level of Rce1 was positively cor－related with Gleason score and N stage（P=0.030，P=0.039）. With the optimal cut-off value of 74.98 pg/μL，Rce1 had a sensitivity of 89.7% and a specificity of 46.3%. The area under the receiver operating characteristic curve of combined diagnosis with Rce1 and prostate specific antigen（PSA） was higher than each diagnostic method alone（P=0.000）. Conclusion：Blood Rce1 test is helpful to improve the early diagnosis rate of PCa，and Rce1 combined with PSA also can improve the diagnostic efficiency of PCa. Therefore，Rce1 is deemed as a new marker for the screening for and prognosis of PCa.

Abstract:Objective：To explore the application of the ultrasonographic descriptors in the fifth edition（2013 update） of the Breast Imaging Reporting and Data System（BI-RADS） ultrasound（US） lexicon combined with relevant clinical data in the diagnosis of breast cancer，and to evaluate the diagnostic value of the new edition of the BI-RADS US lexicon for breast cancer. Methods：The ultrasono－grams of 2 860 masses were retrospectively reviewed by three independent sonographers with reference to the collected clinical data，and the masses were classified into different categories according to the new edition of the BI-RADS US lexicon. The diagnostic efficacy of the new edition of BI-RADS-US classification was calculated using the receiver operating characteristic（ROC） curve with pathological results as the gold standard，and the recorded ultrasonographic descriptors and collected clinical data were first analyzed by univariate analysis，and the indicators of statistical significance were further analyzed by multivariate logistic regression analysis. Results：According to the new edition of BI-RADS-US for the diagnosis of breast cancer，the malignancy rate was 0.66% in BI-RADS category 2，0.99% in BI-RADS category 3，9.57% in BI-RADS category 4a，32.31% in BI-RADS category 4b，88.36% in BI-RADS category 4c，and 94.19% in BI-RADS category 5. With BI-RADS category 4a as the cut-off point，the new edition of BI-RADS-US for the diagnosis of breast cancer had a sensitivity of 88.55%，a specificity of 92.17%，an accuracy of 91.75%，an AUC of 0.948，and a Youden index of 0.81. Conclusions：The new edition of BI-RADS-US has a high accuracy in the diagnosis and risk stratification of breast cancer. With BI-RADS category 4a as the cut-off point，the new edition of BI-RADS-US has high diagnostic efficacy for breast cancer. The shape，margin，calcification，and blood flow of the mass are important ultrasonographic variables，which clinicians can use for clinical diagnosis and precise treatment with refer－ence to patients’ age and axillary lymph node metastasis.

Abstract:Objective：To investigate the analgesic effect of oxycodone hydrochloride sustained-release tablets combined with gabapentin in the treatment of cancerous neuropathic pain in elderly cancer patients. Methods：A retrospective analysis was performed for the clinical outcome and safety of 60 elderly patients with moderate or above cancerous neuropathic pain who were treated with oxycodone hydrochloride sustained-release tablets alone or combined with gabapentin for more than 14 days in our hospital. There were 30 patients in the combination group and 30 in the monotherapy group，and the two groups were compared in terms of the dose of oxycodone hydrochloride sustained-release tablets，analgesic effect，and quality of life on days 3，7，and 14 of treatment. Adverse reactions were observed for both groups. Results：On days 3，7，and 14 of treatment，the combination group had a significantly lower average daily dose of oxycodone hydrochloride than the monotherapy group（P<0.05）. Both groups had a certain degree of pain relief after treatment，and the combination group had significantly greater pain relief than the monotherapy group（P<0.05）. Both groups had significant improvements in the scores of each item of quality of life at each time point after treatment，and there were significant dif－ferences in the scores of daily activities，mood，sleep，and the pleasures of life between the two groups（P<0.05），while there were no significant differences in walking ability，daily work，and relationship with others between the two groups（P>0.05）. Compared with the monotherapy group，the combination group had significantly lower incidence rates of constipation，nausea，and vomiting（P<0.05） and higher incidence rates of dizziness and somnolence（P>0.05）. Conclusion：In elderly cancer patients with cancerous neuropathic pain，oxycodone hydrochloride sustained-release tablets combined with gabapentin can effectively control the pain，reduce the dose of oxycontin hydrochloride and adverse reactions，and improve their quality of life. Therefore，it holds promise for clinical application.

Abstract:Objective：To investigate the value of radiomics based on dynamic contrast-enhanced magnetic resonance imaging（DCE-MRI） in predicting luminal and non-luminal breast cancer. Methods：A retrospective analysis was performed for the clinical data of 42 patients who underwent breast DCE-MRI and had pathologically confirmed breast cancer. The lesions were outlined by manual segmentation on the images with the strongest enhancement of DCE-MRI to determine radiomic features. Then the least absolute shrinkage and selection operator was used to select the most important features. All patients were divided into luminal group and non-luminal group according to the expression of estrogen receptor（ER） and progesterone receptor（PR）. Classifiers were constructed based on logistic regression（LR），random forest（RF），K nearest neighbor（KNN），and support vector machine（SVM），and the 5-fold cross validation method was used to verify prediction performance. Results：A total of 4 optimal features were screened out，consisting of 1 shape feature and 3 wavelet features，among which Original_Shape_Maximum 2D Diameter Row，Wavelet-LLH_GLCM_Idn，and Wavelet-HHH_GLCM_Correlation had significant correlations with ER and PR levels. The RF-based classifier had the best performance in predicting luminal and non-luminal breast cancer，with a sensitivity of 0.838，a specificity of 0.900，an accuracy of 0.853，and an area under the ROC curve of 0.876. Conclusion：Radiomics based on DCE-MRI has a good value in predicting luminal and non-luminal breast cancer，and the RF-based classifier has the best performance.

Abstract:Objective：To investigate the clinical effect and safety of Qiteng Tongbi fumigant combined with ganglioside in preventing neurotoxicity caused by mFOLFOX6 chemotherapy in colorectal cancer patients，and to provide clinical evidence for integrated tradi－tional Chinese and Western medicine therapy in the treatment of peripheral neurotoxicity caused by chemotherapy. Methods：A total of 180 colorectal cancer patients who met the inclusion criteria and received mFOLFOX6 chemotherapy were randomly divided into treatment group 1（Qiteng Tongbi fumigant combined with ganglioside+chemotherapy），treatment group 2（ganglioside+chemotherapy），and control group（chemotherapy alone），with 60 patients in each group. Each course of treatment was 14 days，and all patients were treated for 12 courses. The three groups were evaluated and compared in terms of the incidence rate of peripheral neurotoxicity caused by oxaliplatin，electromyography（EMG） changes，and adverse reactions after treatment. Results：There was a significant differ－ence in the incidence rate of peripheral neurotoxicity between the treatment group 1，the treatment group 2，and the control group（χ2=21.899，P=0.000）. The time to peripheral neurotoxicity in the three groups was （129.920±4.615），（104.680±3.912），and （49.190±3.699） d，respectively，and there was a significant difference between the three groups（F=4 422.520，P=0.000）. There were significant differences between the three groups in sensory nerve conduction velocity（SNCV） and motor nerve conduction velocity（MNCV） of the common peroneal nerve[SNCV：（52.74±4.01） m/s vs. （45.55±4.21） m/s vs. （35.79±7.67） m/s，F=135.472，P=0.000；MNCV：（48.98±3.95） m/s vs. （44.69±4.18） m/s vs. （37.89±6.65） m/s，F=70.334，P=0.000]. There were no significant differences in the incidence rates of major adverse reactions between the three groups（P>0.05）. Conclusion：Qiteng Tongbi fumigant combined with ganglioside can significantly reduce the incidence rate of peripheral neurotoxicity caused by mFOLFOX6 chemotherapy and does not increase treatment-related adverse reactions. It is expected to become a superior and non-toxic treatment method for neurotoxicity caused by the chemotherapy drug oxaliplatin and holds promise for clinical application.

Abstract:Objective：To investigate the influencing factors for postoperative quality of life（QOL） in patients with oral and maxillofa－cial malignancies（OMMs）. Methods：A total of 90 patients with oral and maxillofacial malignancies（OMMs） who underwent surgical treatment in a grade A tertiary stomatological hospital in China from January 2016 to March 2018 were selected as subjects. Twenty-nine factors of demography，social psychology，and medical care were collected by on-site interviews，questionnaires，and data mea－surements. The postoperative QOL of patients was evaluated using Functional Assessment of Cancer Therapy-Head and Neck-V4 [FACT-H&N（V4）]. Independent factors for postoperative QOL were analyzed by univariate and multivariate analyses. Results：The univariate and multivariate analyses showed that segmental resection of lower jaw bone（OR=50.897，95%CI=1.319 to 1 964.684，P=0.035），M.D. Anderson Dysphagia Inventory（MDADI） score（OR=1.260，95%CI＝1.086 to 1.462，P=0.002），good social support（OR=677.074，95%CI＝1.166 to 381 787.087，P=0.045） and mini nutritional assessment（MNA） score（OR=28.788，95%CI＝1.151 to 719.778，P=0.041） were independent influencing factors for the QOL of patients with OMMs. Conclusion：It is an effective way to improve the postoperative QOL of patients with OMMs by retaining the continuity of lower jaw bone，reconstructing swallowing func－tion and improving nutritional status and social support.

Abstract:Objective：To observe the expression of TNF-α，TWEAK，Fn14 on the treat of tumor cachexia with Shenlingbaizhu powder. Methods：Sixty-four tumor cachexia patients were randomized into treatment group and control group，with thirty-two in each. The control group was given nutritional support and the treatment group was given Shenlingbaizhu powder in addition. The effect was evaluated after 4 weeks. The clinical symptoms，kanrofsky score（KPS），tumor necrosis factor-α（TNF-α），tumor necrosis factor-like weak inducer of apoptosis（TWEAK） and fibroblast growth factor-inducible 14（Fn14） were observed. Results：After treatment，the total effective rates of the Chinese medicine symptom in treatment group and control group were 40.62% and 15.62% respectively，with significant differences between groups（P<0.05）. After treatment，the KPS improvement rate was improved significantly in treatment group（P<0.05）. After treatment，the TNF-α，TWEAK and Fn14 were reduced significally in treatment group（P<0.05）. Conclusion：Shenlingbaizhu powder combined with nutritional support can improve life quality and KPS，decrease TNF-α，TWEAK，Fn14 expres－sion of the tumor cachexia patient. Shenlingbaizhu powder control cancer cachexia maybe due to its regulation of these cytokines.

Abstract:Objective：To measure the labeling rate，radiochemical purity，and specific activity of 131I-labeled recombinant human thy－rotropin（rhTSH） as a targeting probe，and to investigate the distribution in vivo and radioimmunoimaging（RII） of 131I-rhTSH in a human differentiated thyroid carcinoma（DTC）-bearing nude mice model. Methods：rhTSH was labeled with 131I by the chloramine T method，and radioactively labeled rhTSH was purified using Sephadex G25M column. The labeling rate，radiochemical purity，room temperature stability，and serum stability were determined using paper chromatography，and the specific activity was calculated. Fur－thermore，the biodistribution and RII of the radioactively labeled drug in the K1 nude mice model were studied. Results：The labeling rate，radiochemical purity，and specific activity of 131I-rhTSH were（93.04±1.13）%，（97.71±1.14）%，and（4.92±0.06） MBq/μg，respectively. The radiochemical purity of 131I-rhTSH placed at room temperature for 1，6，12，and 24 hours was（92.94±0.34）%，（91.81±0.64）%，（91.38±1.20）%，and（90.43±0.74）%，respectively；after incubation with serum for 1，6，12，and 24 hours，the radiochemical purity was（92.59±0.73）%，（91.33±0.98）%，（91.01±0.73）%，and（89.58±1.33）%. Biodistribution and single photon emission computed tomography in the tumor-bearing K1 nude mice model showed that 131I-rhTSH was selectively concentrated in tumor tissues and the target/non-target ratio reached the highest at 24 hours with the clearest tumor imaging. Conclusion：The 131I-rhTSH molecular probe was successfully prepared，which has a good targeting effect in DTC-bearing nude mice model，laying a foundation for further diagnosis and treatment of DTC.

Abstract:Objective：To retrospectively validate the Caprini risk assessment model for predicting the risk of peripherally inserted cen－tral catheter（PICC）-related venous thrombosis in tumor patients. Methods：A case-control study was conducted to collect general data and catheterization data from 150 patients who underwent PICC catheterization from 2012 to 2017. Tumor patients with confirmed PICC-related venous thrombosis were enrolled in case group，and according to the tumor type，the 1∶4 paring method was used to enroll catheterized patients without PICC-related venous thrombosis in control group. According to the Caprini risk assessment model，the two groups of patients were scored，recorded，and compared. A multivariate logistic regression analysis was performed to analyze risk factors，as well as the relationship between risk stratification and the risk of PICC-related venous thrombosis in tumor patients. Results：The Caprini score of the case group（7.720±1.768） was higher than that of the control group（6.220±1.097）. In the case group，the proportion of patients with a PICC-related venous thrombosis score of 7 or more was as high as 72%，which was signifi－cantly higher than that of the control group（P=0.000）. Logistic regression analysis with the risk factors as the independent variables showed that severe lung diseases（OR=5.539，95% CI=1.799 to 17.053，P=0.003），history of thrombosis（OR=24.735，95%CI=3.624 to 168.822，P=0.001），and other high-risk factors（OR=6.987，95%CI=2.105 to 23.196，P=0.001） were main risk factors for PICC-related venous thrombosis in tumor patients. Conclusion：The Caprini risk assessment model can effectively predict the risk of PICC-related venous thrombosis in tumor patients and is worthy of clinical promotion.

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